Zusammenfassung
Drogen mit dem Anspruch, als Antidiabetika zu wirken, sind in der Volksmedizin weit
verbreitet. Ein Nachweis ihrer Wirkung fehlt jedoch oft. Basierend auf den Kenntnissen
über polyphenolische alpha-Amylasehemmstoffe aus Pflanzen untersuchten wir Artischockenzubereitungen
auf diese Wirkung. Zusammen mit der Fähigkeit, die postprandialen Blutzuckerspitzen
zu vermindern und den Effekten auf den Lipidstoffwechsel könnten Artischockenzubereitungen
als adjuvante Phytotherapeutika zur Beeinflussung der Stoffwechsellage beim metabolischen
Syndrom eingesetzt werden.
Summary
Type 2 diabetes: a rationale indication for artichoke?
Antidiabetics of plant origin are commonly used. However, a proof of their efficacy
or their mode of action is often missing. Based on the knowledge about polyphenolic
inhibitors of alpha-amylase from plants we selected artichoke preparations for investigating
the alpha-amylase inhibiting properties. Due to their ability to lower the postprandial
blood glucose level in addition to its lipid-lowering effect, artichoke might be a
useful adjuvant drug to influence the metabolic condition in case of metabolic syndrome.
Schlüsselwörter
alpha-Amylasehemmer - Diabetes - Arzneipflanzen - Artischocke
Key words
Inhibitors of alpha-Amylase - diabetes - herbal medicinal plants - artichoke - metabolic
syndrome
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Prof. Dr. Matthias F. Melzig
Institut für Pharmazie der Freien Universität
Berlin
Königin-Luise-Str. 2+4
14195 Berlin
Email: melzig@zedat.fu-berlin.de
Online
http://dx.doi.org/10.1055/s-0030-1262400
